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Genetically modified anti-Zika mosquito environmentally safe, says FDA

The male mosquitoes are modified so their offspring will die before reaching adulthood and being able to reproduce.

FILE - In this Jan. 18, 2016 file photo, a researcher holds a container with female Aedes aegypti mosquitoes at the Biomedical Sciences Institute in the Sao Paulo's University in Sao Paulo, Brazil. The spread of the Zika virus in Latin America is giving a boost to a British biotech firm’s proposal to try reducing the threat by deploying a genetically modified version of the mosquito that transmits the disease.  (AP Photo/Andre Penner, File) FILE – In this Jan. 18, 2016 file photo, a researcher holds a container with female Aedes aegypti mosquitoes at the Biomedical Sciences Institute in the Sao Paulo’s University in Sao Paulo, Brazil. The spread of the Zika virus in Latin America is giving a boost to a British biotech firm’s proposal to try reducing the threat by deploying a genetically modified version of the mosquito that transmits the disease. (AP Photo/Andre Penner, File)

U.S. health regulators said a genetically engineered mosquito being used in the fight against Zika will not have a significant impact on the environment, possibly paving the way for the technique to be used in the country.

The self-limiting strain of the Aedes aegypti mosquito was developed by Oxitec, the U.K.-subsidiary of U.S. synthetic biology company Intrexon Corp. The male mosquitoes are modified so their offspring will die before reaching adulthood and being able to reproduce.

Preliminary findings of an investigational trial by the U.S. Food and Drug Administration conducted in the Florida Keys region ruled that the genetically modified mosquitoes will not have a significant impact on the environment, effectively agreeing with an environmental assessment submitted by Oxitec.

The findings come on the heels of rising concern over Zika virus in the United States, with Florida declaring a public health emergency last month.

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Zika virus, first detected in Africa in the 1940s, was unknown in the Americas until last year when it appeared in northeastern Brazil, where it has been linked to a spike in birth defects in thousands of babies.

Florida’s warm climate and nearly year-round mosquito season make it particularly vulnerable to spreading, although so far all of the state’s cases were acquired abroad, officials have said.

“If we do get permission from the FDA to go ahead, we are hoping that we will start running the program sometime in 2016,” Oxitec Chief Executive Hadyn Parry said on a media call on Friday.

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Oxitec, which was spun off from Oxford University, was acquired last year by Intrexon.

Efficacy trials in Brazil, Panama, and the Cayman Islands showed that this approach has helped reduce the Aedes aegypti population by more than 90 percent, Oxitec said.

Parry added that until now mosquito control techniques in the United States have only been able to reduce population by about 50 percent.

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However, the concept of wiping out an entire mosquito species also raises ecological questions, as it runs counter to preserving biodiversity.

A petition on Change.org by Mila de Mier, a Key West resident, has gathered more than 161,000 supporters, and calls for the FDA to not approve the genetically modified mosquitoes.

First published on: 12-03-2016 at 07:48:26 am
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